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News; Chaussures De Foot Nike Mercurial Victory VI IC Bleu Royal Chrom

Published: vendredi 14 juillet 2017

Views of the nicotinic acetylcholine receptor. A: Schematic representation of receptor as it appears in the plasma membrane. Five protein subunits, each spanning the lipid bilayer, come together to form a pore through the cell membrane. The pore through which ions can travel is seen in the middle of the structure. Greek letters denote the four different types of subunits that exist; a functional channel is composed of a combination of different subunit types (see text). B: Transmembrane topology of a single subunit of the nicotinic acetylcholine receptor. The subunit is Nike Mercurial Superfly IC shown stretched out in order to see the individual domains, though in reality the structure is more compact and corresponds to an individual cylinder in the representation seen in part A. Transmembrane domains are labeled M1M4.

The large Nterminal domain contains the ligandbinding domain in a subunits and faces the synaptic cleft. The M2 domain faces the inside of the channel pore and determines the ionic selectivity based on its amino acid composition. View larger size Figure in a new windowAlthough highly homologous, nAChR of the periphery and the central nervous system differ in some key aspects. The adulttype neuromuscular variant of the channel is present exclusively Chaussures De Foot Nike Mercurial Pas Cher in the cell membrane of skeletal muscle and consists of two copies of the a1 subunit each of which contains a single ligand binding domain along with one b, one d, and one e subunit (3).